Nanotoxicology and nanomedicine: The Yin and Yang of nano-bio interactions for the new decade
Publications | June 1, 2021

Nanotoxicology and nanomedicine are two sub-disciplines of nanotechnology focusing on the phenomena, mechanisms, and engineering at the nano-bio interface. For the better part of the past three decades, these two disciplines have been largely developing independently of each other. Yet recent breakthroughs in microbiome research and the current COVID-19 pandemic demonstrate that holistic approaches are crucial for solving grand challenges in global health.

In this nanotoday review, CBNS members Dr Ibrahim Javed, Dr Aleksandr Kakinen, Centre Director Professor Tom Davis and Professor Pu-Chun Ke collaborate with three of the CBNS visiting professors to show the Yin and Yang relationship between the two fields by highlighting the shared goals of making safer nanomaterials, improved cellular and organism models, as well as advanced methodologies.

Fig. 1. A meta-analysis of research emphases in nanotoxicology versus nanomedicine. (Top) Lexicons of nanotoxicology (magenta) and nanomedicine (navy blue), extracted on the 31st of July, 2020 from two representative journals: Nanotoxicology (Taylor and Francis) and Nanomedicine: Nanotechnology, Biology and Medicine (Elsevier) using Web of Science (Clarivate Analytics). The keywords used for the search (except for “virus” and “microbiome”, which were added as emerging research directions) were selected from the most frequently used words from the Perspectives by Fadeel et al., Faria et al., and Pelaz et al., identified by WordCounter. (Bottom) Similarities and differences between nanotoxicology and nanomedicine research foci, extracted from the top panel.