Dr Sifei Han
Research Fellow
Monash University

Biography

Sifei’s research has focused on using lipid-mimetic prodrug strategies to enable drug loading to lipoproteins – nm to µm sized endogenous lipid carriers produced by animals and humans. This approach promotes drug transport to the lymphatic system and may be used to enhance the delivery of immunomodulatory drugs to the target site, providing opportunities to improve treatment of conditions such as (auto)immune disorders where the lymphatic system is closely involved. Via redirecting drug transport to the lymphatics rather than the blood stream after oral absorption, this approach also improves the oral bioavailability of drugs and drug candidates that are normally subject to significant hepatic first-pass metabolism.

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