Microenvironment responsive intelligent nanoprobes for precision diagnosis and theranostics

Project Summary

Nanomedicine seeks to exploit the nanoscale properties and the first generation of nanoprobes that have been clinically translated has already leveraged such nanoscale properties to achieve improved diagnostic or therapeutic capabilities. The second generation nanoprobes will be strongly engaged with the disease microenvironment such as redox potential, pH, ionic strength, ROS, hypoxia, enzyme activity to enable responsive effect for the physiological changes.

Responsive polymer-based nanomaterials have provided a successful paradigm for developing intelligent probes. Based on the polymer scaffold, precision medicine and theranostics can be achieved by incorporating different functional groups that is highly specific to the disease environment.