Tumour spheriod design

Project Summary

Novel tumour spheroids have been designed using a chemically well-defined 3D cell culture matrix based on self-assembled peptides. CBNS scientists have shown that this 3D cell culture can support the growth of SK-N-BE(2)-luc neuroblastoma multicellular tumour spheroids for up to 72 hours without any detectable adverse reaction.

The advantage of this approach is that it moves away from the use of chemically complex and heterogeneous biological (e.g. Matrigel®) and synthetic polymer-based 3D cell culture matrix materials which are less reproducible and therefore complicate interpretation of in vitro drug efficacy and delivery studies.