Theranostic devices

Project Summary

A key area of focus for the CBNS is understanding how to control bio-nano interactions. Such control importantly allows the directing of materials to specific tissue.

Using animal models in which multiple different tumour-types are grown simultaneously, CBNS researchers have shown that nanomedicines can be developed that selectively show high affinity for one or the other tumour type, depending on expression levels of specific proteins.

In particular, prostate cancer was used as a model system and clearly demonstrated that the propensity for a nanomedicine to accumulate within a xenograft tumour was very much driven by target-receptor density, with minimal accumulation due to the so-called enhanced permeability and retention (EPR) effect.