Overcoming challenges of in vivo targeting
Signature Project

Project Leaders

Professor Kris Thurecht, Professor Frank Caruso


Dr Zach Houston, Dr Matt Faria


The Project

To develop an in-depth understanding of the role that the physicochemical properties of nanomaterials have on overcoming the different biological barriers that can impede nanoparticle accumulation in tissue.


The Big Questions

  • Can we directly assess the contribution that targeting cellular proteins has on the degree of accumulation of nanomedicines within disease tissue? Is it really beneficial to use active targeting? This includes assessment of how active targeting influences immune response accumulation in disease tissue.
  • How do targeting ligands affect intra-tissue distribution and ultimate efficacy of imaging agent/therapeutic? Does the targeting ligand affect how the drug or therapeutic is distributed throughout the disease site and consequently its efficacy?


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