Developing predictive models of bio-nano interactions
Signature Project

Project leader

Professor Stephen Kent (Melbourne)

The big question

How can we better understand and predict how nanomaterials interact with cellular environments?

Research outline

One of the key challenges associated with translating nanomaterials into vaccines and other therapeutics is understanding how nanomaterial characteristics interact with cellular environments. The development of predictive relationships between structure, function and subsequent physiological response will drive the rational design of novel nanomedicines. These relationships are often determined by the intrinsic characteristics of nanoparticles, such as chemical composition, size, surface charge, architecture, roughness and surface chemistry. Throughout 2016, multiple CBNS collaborations investigated how material properties can affect immune cell-nanoparticle interactions.