How does cellular heterogeneity affect the progression of a disease and prognosis/treatment of a patient?
Cellular heterogeneity within diseased tissue plays a key role in the progression of diseases which has implications for their therapeutic treatments. Information collected from ensemble measurements can potentially mask these rare but important events, such as the spread of the disease and response to a therapy.
The ability to select single diseased cells out of a complex population of cells will clearly be of benefit to better understand the variation of association and internalisation at the single cell level of new nanomedicines that are developed by CBNS groups.
By analysing the single diseased cells that show to be vital to the progression of the disease and a low level of nanomedicine internalisation, through methods such as single-cell mass spectrometry and single-cell gene sequencing, a better understanding of these cells can be gained that will shape the development of the next generation of targeted nanomedicines.