Effective drug delivery depends on delivering drugs to the sites in the cell where they are therapeutically active – and nanoparticles are
seen as effective strategy for the future. The aim of this signature project is to gain a fundamental understanding of how nanoparticles
are trafficked in cells.
In particular, we are focusing on understanding how nanoparticles and their cargo are internalised, trafficked in the endosomes and trafficked from the endosome into the cytoplasm (i.e. endosomal escape). These fundamental interactions are poorly understood and by understanding these interactions, we aim to engineer the next generation of nanoparticles that can respond intelligently to the cellular environment.
Can we improve the effectiveness of drugs by controlling where they are trafficked in cells?
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