Nanoparticle delivery systems have the potential to improve the treatment of various diseases. Understanding how these nanoparticles are internalised by cells and then processed within the cells is critical for understanding how nanoparticles can reach their site of action.
Endocytosis is a critical step in the process by which many therapeutic nanomedicines reach their intracellular targets. Our understanding of cellular uptake mechanisms has developed substantially in the past five years. However, these advances in cell biology have not fully translated to the nanoscience and therapeutics literature.
In the Nature Nanotechnology review article, Joshua Rennick, CI Dr Angus Johnston and CI Professor Rob Parton present an overview of the current understanding of endocytosis, and the limitations of current experimental techniques, in the hope of stimulating research directed at understanding how a nanoparticle is internalised in target cells in vivo, and how an understanding of this process can dictate therapeutic strategies.